Inflammation-based biomarkers for the prediction of nephritis in systemic lupus erythematosus

Background/Aim: Inflammation is a crucial component in the pathophysiology of systemic lupus erythematosus (SLE) nephritis. Immune-based scores, such as neutrophil-lymphocyte and platelet-lymphocyte ratios (NLR PLR, respectively) have been suggested predictors inflammation prognosis SLE. This study aimed to investigate value immune-inflammation index (SII), inflammatory prognostic (IPI), response (SIRI) SLE nephritis (LN). Methods: case-control consisted 108 newly diagnosed patients (separated into two subgroups, which included 34 with biopsy-proven LN 74 without nephritis) age- gender-matched healthy controls who presented our outpatient clinic between October 2015 June 2020. Patients malignancy, lymphoproliferative hematologic disorders, active infection, autoimmune diseases other than were excluded. Inflammation-based biomarkers calculated at first presentation disease before any medication was administered. SII Neutrophil/Lymphocyte x Platelet, SIRI Neutrophil Monocyte/Lymphocyte, IPI CRP NLR/serum albumin. The Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) used measure activity. capability SII, SIRI, NLR, distinguish or assessed using receiver operating characteristic (ROC) curves. Correlations inflammation-based scores (SII, IPI, NLR) activity laboratory data analyzed. Results: significantly higher (P=0.003, P=0.019, P<0.001, also those (P<0.001, P=0.009, P=0.007, respectively). area under curve (AUC) for terms differentiating 0.748, 0.690, 0.663, respectively. cut-off predict 552.25 (sensitivity: 64.7%; specificity: 64.9%; P<0.001), 1.08 61.8%; 62.2%; P=0.002), 4.48 specificity, P=0.007), Conclusion: may be valuable promising presence patients. found most reliable predictor among study.